1984 - BS, Mangalore University, Mangalore, India
1986 - MS, Mangalore University, Mangalore, India
1992 - PhD, Mangalore University, Mangalore, India
Center for Cellular Molecular Biology, Hyderabad, India
Department of Medicine, University of Texas Health Center, Tyler, TX
After completing his postdoctoral training, Dr. Shetty joined the faculty at the UT Heath Center at Tyler as an instructor in 1995. He later accepted a faculty appointment as an Assistant professor in the Department of Medicine, UT Health Center in 1996. In 1998, he was promoted as an Associate Professor of Medicine at the UT Health Center, Tyler. In 2004, Dr. Shetty became a full professor in the Department of Medicine, at the University of Texas Health Center, Tyler. Ten years later he also became professor of Cellular and Molecular Biology at the UT Health Science Center at Tyler, Texas.
Dr. Shetty’s research is focused on molecular mechanisms of gene expression, posttranscriptional regulation, epigenetics, lung epithelial cell apoptosis, senescence, cell cycle regulation and proliferation, alveolar fibrinolysis, cellular signaling mechanisms and p53 biology. His major research interests are lung epithelial biology, lung diseases such as COPD/emphysema, inflammation, ARDS, lung fibrosis, acute lung injury, infection and sepsis induced acute lung injury. Development and testing of interventions that target coordinate regulation of majory components of uPA fibrinolytic system (uPA, uPAR and PAI-1) by the tumor suppressor protein, p53 to treat acute and chronic lung injuries and fibrotic remodeling of lungs using preclinical animal models.
Amarnath S Marudamuthu, PhD
Nivedita Tiwari, PhD
Bijesh Puthusseri, PhD
Taryn B Hogan, MS
Marudamuthu AS, Shetty SK, Bhandary YP, Karandashova S, Thompson M, Sathish V, Florova G, Hogan T, Pabelick C, Prakash YS, Idell S and Shetty S (2015) Plasminogen activator inhibitor-1 suppresses pro-fibrotic responses in fibroblasts from fibrotic lungs. J Biol Chem. 290(15):9428-9441.PMID: 25648892.
Marudamuthu AS, Bhandary YP, Shetty SK, Fu J, Sathish V, Prakash YS and Shetty S (2015) Role of the Urokinase-fibrinolytic system in epithelial mesenchymal transition during lung injury. Am J Pathol 185(1)55-68. PMID: 25447049
Bhandary YP, Shetty SK, Marudamuthu AS, Fu J, Pinson BM, Levin J and Shetty S (2015) Role of p53-fibrinolytic system cross-talk in the regulation of quartz-induced lung injury. Toxicol Appl Pharmacol 283(2)92-98. PMID: 25596429.
Bhandary YP, Shetty SK, Marudamuthu AS, Midde KK, Idell S, Ji HL, Shams A, Fu J, and Shetty S (2015) Plasminogen Activator Inhibitor-1 in cigarette smoke exposure induced lung injury and influenza A virus infection PLoS One 10(5) e0123187. PMID: 25932922.
Gao R, Hu Y, Chen J, Shetty S, Ma, Z and Fu J. Sirt1 restrains lung inflammasome activation in a murine model of sepsis. Am J Physiol- Lung Cell Mol Physiol. (in press), 2015.
Chen Z, Zhao R, Zhao M, Liang X, Bhattarai D, Dhiman R, Shetty S, Idell S, Ji HL. Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency. Am J Physiol Lung Cell Mol Physiol. 307:L609-L617, 2014.
Gao R, Chen J, Hu X, Li Z, Wang, S, Shetty S and Fu J. Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury. PlosOne 9(6) e98909, 2014.
Chen I, Shetty S, Zhang P, Gao R, Hu Y, Wang S, Li Z, and Fu J. Aspirin-triggered Resolvin D1 down-regulates IL-6 signaling and protects against endotoxin-induced acute kidney injury. Toxicol Appl Pharmacol 277(2):118-23, 2014.
Bhandary YP, Shetty SK, Marudamuthu AS, Ji H, Boggaram, VB, Neuenschwander PF, Morris GB, Fu J, Idell S and Shetty S (2013) Regulation of alveolar epithelial injury and lung remodeling by p53-mediated changes in urokinase and plasminogen activator inhibitor-1. Am J Pathol 183,131-143. PMID: 23665346.
Shetty SK, Bhandary YP, Marudamuthu AS, Abernathy D, Veluswamy T, Starcher B, Shetty S (2012) Regulation of Airway and Alveolar Epithelial Cell Apoptosis by p53 Induced PAI-1 During Cigarette Smoke Exposure Injury. Am J Respir Cell Mol Biol 47:474-483. PMID:22592924.
Shetty SK, Marudamuthu AS, Abernathy D, Shetty RS, Shetty P, Fu J, Idell S, Bhandary YP, Ji H, Liu MC, and Shetty S. Regulation of urokinase expression at the posttranscription level by lung epithelial cells. Biochemistry 51:205-213, 2012. PMID: 22166006.
Bhandary YP, Shetty SK, Marudamuthu AS, Gyetko MR, Idell S, Gharaee-Kermani M, Shetty RS, Starcher BC, Shetty S (2012) Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system. Am J Physiol Lung Cell Mol Physiol 302(5): L463-473. PMID: 22140072.
Midde KK, Batchinsky AI, Cancio LC, Shetty S, Komissarov AA, Florova G, Walker KP, III, Koenig K, Chroneos ZC, Allen T, Chung K, Dubick M, and Idell S. Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cells. Shock 36:128-137, 2011.
Yasuda S, Yasuda T, Liu MY, Shetty S, Idell S, Boggaram V, Suiko M, Sakakibara Y, Fu J, and Liu MC. Sulfation of chlorotyrosine and nitrotyrosine by human lung endothelial and epithelial cells: role of the human SULT1A3. Toxicol Appl Pharmacol 251:104-109, 2011.
Shetty, S, Bhandary YP, Shetty SK, Velusamy T, Shetty P, Bdeir K, Gyetko MR, Cines DB, Idell S, Neuenschwander PF, Ruppert C, Guenther A, Abraham E and Shetty RS (2010) Induction of Tissue Factor by Urokinase in Lung Epithelial Cells. Am J Resp Crit Care Med 181:1-12. PMID: 20194819.